AO-128, ALPHA-GLUCOSIDASE INHIBITOR - ANTIOBESITY AND ANTIDIABETIC ACTIONS IN GENETICALLY OBESE-DIABETIC RATS, WISTAR FATTY

Antiobesity and antidiabetic actions of the alpha-glucosidase inhibito r AO-128 were examined using genetically obese-diabetic rats,Wistar fa tty, Ten-week-old, male fatty rats were kept on CE-2 diet containing 1 0 or 25 ppm of AO-128 for 4 weeks, The average drug intake was calcula ted to be 0.74 or 1.78 mg/kg/day from the average food intake, respect ively. The intestinal maltase and sucrase activities were decreased by AO-128 in a dose-related fashion, Food intake of fatty rats treated w ith AO-128 was decreased throughout the experiment, This decrease in f ood intake could hardly be explained only by diarrhea which occurred f or the first 5 days of the administration of AO-128, AO-128 normalized hyperglycemia and markedly reduced hypertriglyceridemia and hyperinsu linemia in fatty rats, In addition, AO-128 decreased body weight gain, food efficiency, epididymal adipose tissue weight, carcass weight, an d body fat deposition. These findings indicate that AO-128 may be usef ul for treating human obesity and diabetes.