ENANTIOSPECIFIC SYNTHESIS OF SB-214857, A POTENT, ORALLY-ACTIVE, NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST

Authors
MILLER WH KU TW ALI FE BONDINELL WE CALVO RR DAVIS LD ERHARD KF HALL LB HUFFMAN WF KEENAN RM KWON C NEWLANDER KA ROSS ST SAMANEN JM TAKATA DT YUAN CK
Citation
Wh. Miller et al., ENANTIOSPECIFIC SYNTHESIS OF SB-214857, A POTENT, ORALLY-ACTIVE, NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST, Tetrahedron letters, 36(52), 1995, pp. 9433-9436
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
52
Year of publication
1995
Pages
9433 - 9436
Database
ISI
SICI code
0040-4039(1995)36:52<9433:ESOSAP>2.0.ZU;2-O
Abstract
An enantiospecific synthesis of SE 214857, a potent, nonpeptide fibrin ogen receptor antagonist, is reported. The synthetic route employs as a key step an intramolecular aryl fluoride displacement to form the se ven-membered ring of the 1,4-benzodiazepine system.