THE RED-CELL LW BLOOD-GROUP PROTEIN IS AN INTERCELLULAR-ADHESION MOLECULE WHICH BINDS TO CD11 CD18 LEUKOCYTE INTEGRINS/

Authors
BAILLY P TONTTI E HERMAND P CARTRON JP GAHMBERG CG
Citation
P. Bailly et al., THE RED-CELL LW BLOOD-GROUP PROTEIN IS AN INTERCELLULAR-ADHESION MOLECULE WHICH BINDS TO CD11 CD18 LEUKOCYTE INTEGRINS/, European Journal of Immunology, 25(12), 1995, pp. 3316-3320
Citations number
35
Categorie Soggetti
Immunology
Journal title
European Journal of Immunology → ACNP
ISSN journal
00142980
Volume
25
Issue
12
Year of publication
1995
Pages
3316 - 3320
Database
ISI
SICI code
0014-2980(1995)25:12<3316:TRLBPI>2.0.ZU;2-A
Abstract
Leukocyte adhesion involves the leukocyte-specific integrins CD11a/CD1 8, CD11b/CD18 and CD11c/CD18, which bind to intercellular adhesion mol ecules (ICAM). Three ICAM have been described, and are expressed on le ukocytes and various other cells, but are absent from red cells. Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycopr otein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology.