MODIFICATION BY MUSCIMOL OF NALOXONE-PRECIPITATED WITHDRAWAL SYMPTOMSIN MORPHINE-DEPENDENT MICE

Authors
ELKADI AOS SHARIF SI
Citation
Aos. Elkadi et Si. Sharif, MODIFICATION BY MUSCIMOL OF NALOXONE-PRECIPITATED WITHDRAWAL SYMPTOMSIN MORPHINE-DEPENDENT MICE, General pharmacology, 26(7), 1995, pp. 1579-1581
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
26
Issue
7
Year of publication
1995
Pages
1579 - 1581
Database
ISI
SICI code
0306-3623(1995)26:7<1579:MBMONW>2.0.ZU;2-1
Abstract
1. In morphine-dependent mice, muscimol, a GABA(A) agonist when given i.p. 30 min before naloxone, attenuated the naloxone-precipitated with drawal symptoms of jumping, ''wet dog'' shakes and burrowing, but not body weight loss. 2. Muscimol produced a hypothermic effect which was further aggravated by naloxone.