CHOLESTASIS AS A LIVER PROTECTIVE FACTOR IN PARACETAMOL ACUTE OVERDOSE

Authors
ACEVEDO C BENGOCHEA L TCHERCANSKY DM OUVINA G PERAZZO JC LAGO N LEMBERG A RUBIO MC
Citation
C. Acevedo et al., CHOLESTASIS AS A LIVER PROTECTIVE FACTOR IN PARACETAMOL ACUTE OVERDOSE, General pharmacology, 26(7), 1995, pp. 1619-1624
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
26
Issue
7
Year of publication
1995
Pages
1619 - 1624
Database
ISI
SICI code
0306-3623(1995)26:7<1619:CAALPF>2.0.ZU;2-R
Abstract
1. The effect of paracetamol overdoses on its disposition was investig ated in cholestatic rats. 2. Paracetamol plasma concentration and hepa tic accumulation decrease about 70-80% in cholestatic rats. 3. Cholest atic rats intoxicated with paracetamol showed less hepatic damage as c oncluded from biochemical and histological findings. These data are co rrelated with liver and plasmatic paracetamol. 4. These results indica te a decrease in paracetamol toxicity related to stagnant bile.