CLEAR-CELL ADENOCARCINOMA OF THE COLON

A case of clear cell adenocarcinoma of the colon is reported. The hist ological examination of both the surgical specimen and of the metastas es at necropsy showed columnar or polygonal cells with vesicular nucle i. The cytoplasm was usually clear with multiple, often empty looking vacuoles. From a panel of histochemical and immunohistochemical reacti ons, polypeptide antigen showed strong positivity. The histochemical a nd immunohistochemical differential diagnosis with another common clea r cell tumour, namely clear cell renal adenocarcinoma, is discussed.