ALTERATION BY EGTA OF THE HUMAN RED-CELL CA2-ATPASE()

Authors
ROMERO PJ SALAS V
Citation
Pj. Romero et V. Salas, ALTERATION BY EGTA OF THE HUMAN RED-CELL CA2-ATPASE(), Biochimica et biophysica acta. Biomembranes, 1240(2), 1995, pp. 115-117
Citations number
13
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1240
Issue
2
Year of publication
1995
Pages
115 - 117
Database
ISI
SICI code
0005-2736(1995)1240:2<115:ABEOTH>2.0.ZU;2-T
Abstract
The effect of EGTA on Ca2+-ATPase activity was studied in fragmented m embranes and solubilized preparations from human red cells. A dual act ion was found. At low concentrations (0.1-1 mM), EGTA increased Ca2+ a ffinity without affecting V-max. By contrast, at high concentrations ( 5-10 mM), EGTA was inhibitory. Both effects were partially reversible.