HEPATOBILIARY TOXICITY OF TOTAL PARENTERAL-NUTRITION IN ADULTS

The enzymology and clinical manifestations of total parenteral nutriti on (TPN)-induced liver abnormalities have been investigated extensivel y. The cause, pathogenesis, and treatment of TPN-related hepatic and b iliary dysfunction in adults still are not well understood, however. T he findings of experimental studies in animals has not necessarily cor related with the human data, and Were have been few prospective, rando mized controlled trials examining the mechanism, cause, or treatment o f TPN-induced hepatobiliary toxicity in adults. This article examines the animal models of pathogenesis and treatment of TPN-induced intrahe patic and extrahepatic abnormalities, and provides a discussion of abn ormalities seen in humans.