COMBINED CHORIOCARCINOMA, HEPATOID ADENOCARCINOMA, SMALL-CELL CARCINOMA AND TUBULAR ADENOCARCINOMA IN THE ESOPHAGUS

We describe an oesophageal tumour composed of choriocarcinoma, hepatoi d adenocarcinoma, small cell carcinoma and tubular adenocarcinoma. The choriocarcinomatous areas and hepatoid adenocarcinomatous areas conta ined beta human chorionic gonadotropin-positive cells and alpha fetopr otein-positive cells, respectively. The small cell carcinomatous areas contained cells positive for serotonin or adrenocorticotrophic hormon e, while the tubular adenocarcinomatous areas contained cells positive for carcinoembryonic antigen. Non-neoplastic gastric type columnar ep ithelium was found directly adjoing the tumour at the oral side. This tumour, with its unprecedented histology combination of tissues may ha ve originated in Barrett's oesophagus, although we could not confirm a history of chronic gastro-oesophageal reflux.