SEARCHING FOR A MARKER FOR ALZHEIMERS DISEASE-APO-E

The authors present their study of 10 patients affected by Alzheimer's disease and 10 patients with multinfarctual dementia, who are already part of a CNR study; senile dementia project, longitudinal study. The method adopted was that of DNA crossbreeding and amplification, so as to have a precise individualisation of alleles Apo E-2, Apo E-3, Apo E-4 and of their various phenotype combinations. These isoforms are ev aluated and compared with the disease studied, in order to help to ide ntify a timely marker for senile dementia. On the results obtained we hypothesised an association between Apo E-4 and the disease of about 4 0% for Alzheimer's disease, which leads us to increase our number of c ases, regarding associations between demential diseases either Alzheim er or vascular and the presence of Apo E-4.