Bk. Kitchell et al., INTRALESIONAL SUSTAINED-RELEASE CHEMOTHERAPY WITH THERAPEUTIC IMPLANTS FOR TREATMENT OF CANINE SUN-INDUCED SQUAMOUS-CELL CARCINOMA, European journal of cancer, 31A(12), 1995, pp. 2093-2098
Squamous cell carcinoma (SCC) is the most frequently reported malignan
t epithelial tumour in dogs. Canine sun-induced SCC represents a usefu
l animal model to evaluate new therapeutic modalities for possible hum
an applications. We evaluated the safety and efficacy of treating sun-
induced SCC in dogs with intralesional sustained-released chemotherape
utic gel implants that contained collagen, epinephrine (epi), and eith
er 5-fluorouracil (5-FU) or cisplatin (CDDP). Dogs with large, single
SCC or fields of multiple SCC were treated with 5-FU/epi gel for a min
imum of three weekly injections. Dogs without a complete response were
then treated with CDDP/epi gel for a minimum of three weekly treatmen
ts. We treated from one to 11 primary, recurrent, or refractory SCC pe
r dog (tumour size 0.2-92.4 cm(2); mean cumulative tumour area of 40.7
cm(2) per dog). All dogs had at least 50% reduction in cumulative tum
our area after treatment with 5-FU/epi gel. More than half(seven of 13
) had complete resolution of SCC after treatment with 5-FU/epi gel or
CDDP/epi gel. Minimal local tissue reactions were noted; no systemic t
oxicity occurred. Sustained-release chemotherapy using intralesional 5
-FU/epi gel and CDDP/epi gel therapeutic implants is effective in trea
ting canine sun-induced SCC of the skin.