A CONVENIENT SYNTHESIS OF CHIRAL SUCCINIC ACID-D(2) BY CATALYTIC ASYMMETRIC REDUCTION USING A RUTHENIUN BINAP CATALYST

Authors
SHAHARUZZAMAN M CHICKOS J TAM CN KEIDERLING TA
Citation
M. Shaharuzzaman et al., A CONVENIENT SYNTHESIS OF CHIRAL SUCCINIC ACID-D(2) BY CATALYTIC ASYMMETRIC REDUCTION USING A RUTHENIUN BINAP CATALYST, Tetrahedron : asymmetry, 6(12), 1995, pp. 2929-2932
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
12
Year of publication
1995
Pages
2929 - 2932
Database
ISI
SICI code
0957-4166(1995)6:12<2929:ACSOCS>2.0.ZU;2-7
Abstract
The synthesis of (2R,3R) and (2S,3S) dideuteriosuccinic acid in 63 +/- 10% enantiomeric excess by reduction of the half acid ester of ethyl fumarate from (R) and (S) BINAP ruthenium (II) diacetate complex, resp ectively, is reported. (2R,3R) and (2S,3S)-Dideuteriosuccinic acid has also been prepared from (R)-BINAP ruthenium (II) dicarboxylate comple x directly in similar optical purity by reversing the sequence of intr oduction of the isotopic label.