COMBINED MICROBIAL OXIDATION AND REDUCTION - A NEW APPROACH TO THE HIGH-YIELD SYNTHESIS OF HOMOCHIRAL UNSATURATED SECONDARY ALCOHOLS FROM RACEMATES

Authors
FANTIN G FOGAGNOLO M GIOVANNINI PP MEDICI A PEDRINI P
Citation
G. Fantin et al., COMBINED MICROBIAL OXIDATION AND REDUCTION - A NEW APPROACH TO THE HIGH-YIELD SYNTHESIS OF HOMOCHIRAL UNSATURATED SECONDARY ALCOHOLS FROM RACEMATES, Tetrahedron : asymmetry, 6(12), 1995, pp. 3047-3053
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
12
Year of publication
1995
Pages
3047 - 3053
Database
ISI
SICI code
0957-4166(1995)6:12<3047:CMOAR->2.0.ZU;2-L
Abstract
The oxidation of racemic secondary alcohols with Bacillus stearothermo philus followed by reduction of the mixture with Yarrowia lipolytica t o afford high yields of the enantiomerically pure R-alcohols la,b,d is described. Comparisons with Yarrowia lipolytica reduction, Bacillus s tearothermophilus oxidation, and the contemporary use of the two micro rganisms have been made.