MOLECULAR MECHANISMS OF ENDOTOXIN ACTIVITY

Authors
SCHLETTER J HEINE H ULMER AJ RIETSCHEL ET
Citation
J. Schletter et al., MOLECULAR MECHANISMS OF ENDOTOXIN ACTIVITY, Archives of microbiology, 164(6), 1995, pp. 383-389
Citations number
48
Categorie Soggetti
Microbiology
Journal title
Archives of microbiology → ACNP
ISSN journal
03028933
Volume
164
Issue
6
Year of publication
1995
Pages
383 - 389
Database
ISI
SICI code
0302-8933(1995)164:6<383:MMOEA>2.0.ZU;2-B
Abstract
Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membra ne of the cell wall of gramnegative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular me chanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.