OOCYTE DONATION PROGRAM - PREGNANCY AND IMPLANTATION RATES IN WOMEN OF DIFFERENT AGES SHARING OOCYTES FROM SINGLE-DONOR

Objective: To investigate the importance of uterus age as regards of p regnancy, implantation, and abortion rates using the oocyte donation m odel. Design: Retrospective data analysis of cases where recipients of different ages shared oocytes from single donor. Setting: A tertiary infertility center. Patients: One hundred fourteen women (21 to 49 yea rs of age) undergoing a total of 114 cycles of oocyte donation were di vided into two groups according to age (group A less than or equal to 39 years; group B between 40 and 49 years). Interventions: Hormonal re placement therapy was given using increasing doses of 17 beta-E(2) (2, 4, and 6 or 8 mg) and either 100 mg of P in oil or 600 mg of microniz ed P through the vaginal route. Main Outcome Measures: Pregnancy, abor tion, and implantation rates. Results: Fifty-seven transfer cycles wer e performed per age group. Twenty-seven clinical pregnancies were achi eved in group A and 14 in group B, with pregnancy rates (PRs) of 47.3% and 24.5%, respectively. There were four abortions in group A and one in group B, resulting in abortion rates of 14.8% and 7%, respectively . Thirty-four of 137 transferred embryos in group A and 20 of 134 in g roup B implanted, resulting in implantation rates of 24.8% and 14.9%, respectively. Conclusion: This study seems to suggest that there are d ifferences in pregnancy and implantation rates in recipients of differ ent ages because of uterine receptivity. Fertility therefore does not depend merely on oocyte age and quality but also on uterine age.