DANAZOL VERSUS A GONADOTROPIN-RELEASING-HORMONE AGONIST AS PREOPERATIVE PREPARATION FOR HYSTEROSCOPIC METROPLASTY

Objective: To compare the efficacy of danazol and a GnRH agonist as pr eoperative preparation for hysteroscopic metroplasty in women with sep tate uterus. Design: Prospective randomized clinical study. Setting: T ertiary care center. Patients: Thirty patients with septate uterus. In terventions: The patients were randomized to treatment with danazol 60 0 mg/d for 2 to 4 weeks (n = 15) or with leuprolide acetate depot 3.75 mg for 2 months (n = 15) as preoperative therapy for hysteroscopic me troplasty. Main Outcome Measures: At the intervention the hysteroscopi st evaluated difficulty in dilation of the cervical canal, presence of endometrial fragments, bleeding, difficulty in maneuvering the resect oscope, and operating time. Results: Both the treatments were well tol erated. Metroplasty was simpler overall in the danazol group and also faster in introducing the resectoscope through the cervical canal and maneuvering it in the uterine cavity were both easier. Bleeding was mo dest in both groups and the anatomic outcome of the operation was simi lar. Conclusion: Short preoperative preparation with danazol results i n favorable operating conditions at limited costs with minimal side ef fects.