PECULIARITIES OF MORPHINE AND NALOXONE EF FECTS ON RAT STRAINS WHICH DIFFER BY THE THRESHOLD OF NERVOUS-SYSTEM EXCITABILITY

Authors
SHIRYAEVA NV SEMENOVA SG VAIDO AI LOPATINA NG
Citation
Nv. Shiryaeva et al., PECULIARITIES OF MORPHINE AND NALOXONE EF FECTS ON RAT STRAINS WHICH DIFFER BY THE THRESHOLD OF NERVOUS-SYSTEM EXCITABILITY, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 45(5), 1995, pp. 976-981
Citations number
12
Categorie Soggetti
Physiology,Neurosciences
Journal title
Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova → ACNP
ISSN journal
00444677
Volume
45
Issue
5
Year of publication
1995
Pages
976 - 981
Database
ISI
SICI code
0044-4677(1995)45:5<976:POMANE>2.0.ZU;2-C
Abstract
Effect of morphime and naloxone on nociceptive sensitivity were studie d in 3 rat strains, with high, low, and intermediate thresholds of ner vous system excitability. The highest sensitivity to morphine correlat ed with its dose dependence was revealed in rats with low and high thr esholds of excitability. The lowest sensitivity was found in rats with intermediate thresholds of excitability. The obtained data led to the conclusion about essential contribution of genetical control of excit ability in the mechanisms of functioning of the opiate system.