NITROGEN GLYCOSYLATION REACTIONS INVOLVING PYRIMIDINE AND PURINE NUCLEOSIDE BASES WITH FURANOSIDE SUGARS

Different approaches for the synthesis of nucleoside analogs (potentia l HIV inhibitors) are described. Starting from a suitably substituted furanose ring, it is demonstrated that a high facial stereocontrol of the glycosylation reaction can be effected. Different reaction conditi ons including Lewis acid promoted, S(N)2 displacement and some enzymat ic methodologies for the stereoselective synthesis of these compounds are reviewed.