Ah. Letton et al., TWENTY YEAR REVIEW OF A BREAST-CANCER SCREENING PROJECT - 95 PERCENT SURVIVAL OF PATIENTS WITH NONPALPABLE CANCERS, Cancer, 77(1), 1996, pp. 104-106
BACKGROUND. In 1973, the Breast Cancer Detection Demonstration Project
at the Georgia Baptist Medical Center began screening supposedly asym
ptomatic women for breast cancer. The project has been reviewed and no
w 20 years later, the followup of those women with detected cancer who
were matched with a group of the original cohort with negative screen
s is reported, Early criticism of the project was its ''lead-time bias
,'' which, after 20 pears, should pose no problem. METHODS. Approximat
ely 9043 women were screened for 5 years. The remainder of the total o
f 10,000 women were screened at the Emory University Department of Rad
iology. The 128 patients who were found to have breast cancer were obs
erved for over 20 years. A matched group of 1609, who had negative res
ults when originally screened, were also observed for 20 years. RESULT
S. After 20 years, approximately 86% of the 128 women diagnosed with b
reast cancer were still free of disease, including 88.3% of women with
lesions of less than 1.1 cm and 95.1% of those with nonpalpable carci
nomas. CONCLUSIONS. Over 95% of the 67 women with nonpalpable lesions
were alive after 20 years of follow-up. Women not screened yearly tend
to have larger lesions than those screened on a regular basis. Regula
r screening is currently the best way to control this disease. (C) 199
6 American Cancer Society.