We performed serological testing for a large number of infectious agen
ts in 26 patients from Atlanta who had chronic fatigue syndrome (CFS)
and in 50 controls matched by age, race, and sex, We did not find any
agent associated with CFS. In addition, we did not find elevated level
s of antibody to any of a wide range of agents examined, In particular
, we did not find elevated titers of antibody to any herpesvirus, nor
did we find evidence of enteroviral exposure in this group of patients
.