Inflammatory pseudotumor (IPT) is an uncommon benign neoplasm of uncer
tain etiology that classically has been associated with the lung, wher
e it is generally asymptomatic. In recent years, IPT has been increasi
ngly recognized in other sites. Hepatic, abdominal, and pelvic IPTs pr
oduce a spectrum of nonspecific symptoms including fever, malaise, ane
mia, and weight loss. Because prolonged fever is a prominent feature o
f extrapulmonary IPT, patients with this condition may first come to t
he attention of specialists in infectious diseases. We describe an ill
ustrative case of pelvic IPT and discuss its presentation, diagnosis,
and treatment; we also suggest that infectious disease specialists sho
uld be familiar with this entity as a possible diagnosis for patients
with fever of unknown origin.