RADIATION-INDUCED POLYMERIZATION OF A PHOSPHOLIPID FOR DEVELOPING ARTIFICIAL RED-BLOOD-CELLS

Authors
HOSOI F OMICHI H AKAMA K AWAI K TOKUYAMA S SATOH T
Citation
F. Hosoi et al., RADIATION-INDUCED POLYMERIZATION OF A PHOSPHOLIPID FOR DEVELOPING ARTIFICIAL RED-BLOOD-CELLS, Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, 105(1-4), 1995, pp. 318-321
Citations number
3
Categorie Soggetti
Physics, Nuclear","Nuclear Sciences & Tecnology","Instument & Instrumentation
Journal title
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms → ACNP
ISSN journal
0168583X
Volume
105
Issue
1-4
Year of publication
1995
Pages
318 - 321
Database
ISI
SICI code
0168-583X(1995)105:1-4<318:RPOAPF>2.0.ZU;2-O
Abstract
A phospholipid containing two unsaturated acyl chains, 1,2-bis E,4E-oc tadecadienoyl)-sn-glycero-3-phosphocholine, was polymerized by Co-60 g amma-rays at dose rates 1.65-10 kGy/h at 4 degrees C. The kinetic trea tment of the reaction was carried out. It was found that 2-acyl chain located nearer to the water surface polymerized at first, then l-acyl chain polymerized. The rate of the former reaction was 10 times that o f the latter. The polymerized phospholipid containing haemoglobin was stable at low temperature. The in vivo test with rats was successfully carried out with this artificial red blood cells.