F. Zhang et al., NMDA RECEPTOR ANTAGONIST MK-801 DOWN-REGULATES RAT STRIATAL PROENKEPHALIN AND PROTACHYKININ MESSENGER-RNAS, Neurochemistry international, 28(2), 1996, pp. 189-192
Using quantitative iii situ hybridization, a significant decrease in e
xpression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%)
is observed in the rat caudate-putamen 14 days after daily intraperito
neal administration of N-methyl-D-aspartate receptor antagonist MK-801
, 2 mg/kg.