NMDA RECEPTOR ANTAGONIST MK-801 DOWN-REGULATES RAT STRIATAL PROENKEPHALIN AND PROTACHYKININ MESSENGER-RNAS

Authors
ZHANG F VANBREE L ALBALA N VERSLYPE M VANDERHAEGEN JJ
Citation
F. Zhang et al., NMDA RECEPTOR ANTAGONIST MK-801 DOWN-REGULATES RAT STRIATAL PROENKEPHALIN AND PROTACHYKININ MESSENGER-RNAS, Neurochemistry international, 28(2), 1996, pp. 189-192
Citations number
25
Categorie Soggetti
Biology,Neurosciences
Journal title
Neurochemistry international → ACNP
ISSN journal
01970186
Volume
28
Issue
2
Year of publication
1996
Pages
189 - 192
Database
ISI
SICI code
0197-0186(1996)28:2<189:NRAMDR>2.0.ZU;2-T
Abstract
Using quantitative iii situ hybridization, a significant decrease in e xpression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%) is observed in the rat caudate-putamen 14 days after daily intraperito neal administration of N-methyl-D-aspartate receptor antagonist MK-801 , 2 mg/kg.