CORONARY DILATING EFFECTS OF INTRACORONARY NICORANDIL - COMPARISON WITH ISOSORBIDE DINITRATE

Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a n itrate ester, its cardiovascular action differs from that of nitrate c ompounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0 mg) was compared with that of isosorbide dinitrate (ISDN; 1. 0 mg) in 46 patients with or without ischemic heart disease (IHD). Dos e-dependent right coronary dilating action was observed by intracorona ry administration of nicorandil without any adverse effects. The same degree of right coronary dilation was achieved by the intracoronary ap plication of equivalent doses of ISDN. We conclude that intracoronary administration of nicorandil is beneficial for the supportive treatmen t of IHD during coronary artery investigation and intervention without the risk of severe systemic hypotension.