Infected aortic aneurysms remain a difficult surgical problem associat
ed with high morbidity and mortality. We report three cases of mycotic
thoracoabdominal aneurysms treated by debridement of infected aortic
tissue, in situ prosthetic graft replacement, and intensive antibiotic
therapy. One early death occurred in a patient with systemic sepsis r
elated to Salmonella enteritidis infection of the thoracic aorta secon
dary to a colovesical fistula. The two other patients remain alive at
2 years without further complications of the surgery. Bacteriology is
as follows: Staphylococcus aureus, Streptococcuss pneumoniae, and Salm
onella enteritidis. In all patients the operation was performed immedi
ately after the diagnosis was confirmed. Antibiotic therapy was begun
intraoperatively and was continued for at least 6 months. Two patients
were followed regularly, and there have been no septic recurrences in
our 2-year follow-up period. In situ prosthetic graft replacement in
conjunction with intensive antibiotic therapy is a viable option in th
e treatment of mycotic thoracoabdominal aortic aneurysms.