Approximately 20 per cent of melanomas greater than 0.76 mm in thickne
ss will metastasize to the regional lymph nodes if treated with wide l
ocal excision alone (WLE). Elective lymph node dissection (ELND) is as
sociated with significant morbidity, which includes lymphedema, wound
complications, and paresthesias of the extremity. An alternative opera
tive approach uses selective lymphadenectomy with the identification o
f the sentinel node, defined as the first node in the lymphatic basin
that drains the primary cutaneous site. This study consisted of 132 pa
tients with melanomas greater than 0.76 mm. One hundred nine patients
(83%) had histologic negative sentinel nodes, and 23 patients (17%) ha
d one or more sentinel nodes positive for disease. In patients with me
tastatic disease, 30/35 (86%) sentinel nodes were positive, and 25/357
(7%) nonsentinel nodes were positive (P < 0.001). In 18 patients (78%
) of the 23 patients with metastatic disease, the sentinel node was th
e only node positive, strongly suggesting that there is an orderly pro
gression of metastases. Two patients developed metastatic nodal diseas
e after removal of a negative sentinel node (false negative rate = 1.5
). The mean follow-up was 1 year. Sentinel node histology reflects the
histology of the remainder of the nodes in the lymphatic basin and ''
skip'' metastases, defined as a negative sentinel node but positive no
des higher in the regional chain positive for metastases or an axillar
y recurrence after a negative sentinel node biopsy, are rare for malig
nant melanoma. Harvesting the sentinel node in patients with intermedi
ate or greater thickness melanoma will, therefore, identify a subset o
f patients with metastatic disease who have the most to benefit from a
complete node dissection. This surgical approach allows for complete
pathological staging and therapeutic management of patients while sign
ificantly reducing expense and overall morbidity.