BRONCHIAL EPITHELIAL-CELLS OF ATOPIC PATIENTS WITH ASTHMA LACK THE ABILITY TO INACTIVATE ALLERGENS

The cause of asthma is still unknown. Though most asthmatic patients a re atopic, only certain atopic subjects develop this disease, and atop ic asthmatics recover from asthma after transplantation of lungs from nonasthmatic donors. Thus, there might be a primary local defect in th e bronchial wall which affects the expression of asthma in atopic indi viduals. We show here that the bronchial epithelial cells from atopic patients with asthma are aberrantly permeable to the airborne allergen most often implicated in the pathogenesis of this disease, indicating how it can have access to the antigen-presenting cells (dendritic cel ls) below the apical surface of the epithelium in viva. In addition, a llergen exposure induces asthmatic epithelial cells to express granulo cyte/macrophage colony-stimulating factor, a cytokine involved in the proliferation and function of dendritic cells. (C) 1995 Academic Press , Inc.