M. Kojima et al., A NEW-TYPE SOLUBLE GUANYLYL CYCLASE, WHICH CONTAINS A KINASE-LIKE DOMAIN - ITS STRUCTURE AND EXPRESSION, Biochemical and biophysical research communications, 217(3), 1995, pp. 993-1000
A new type soluble guanylyl cyclase, designated as ksGC (kinase-Like d
omain containing soluble guanylyl cyclase), was identified from a kidn
ey cDNA library. By Northern blot analysis, expression of this novel g
uanylyl cyclase mRNA was found in lung, kidney and skeletal muscle. Al
though ksGC is a soluble type guanylyl cyclasc, it is not a member of
soluble alpha or beta guanylyl cyclases. The ksGC contains in its N-te
rminal region a protein kinase-like domain, which is usually a charact
eristic feature only of particulate type guanylyl cyclases. This uniqu
e feature of ksGC suggests a novel pathway of cGMP synthesis. (C) 1995
Academic Press, Inc.