BIOCONVERSION OF SUBSTITUTED NAPHTHALENES TO THE CORRESPONDING 1,2-DIHYDRO-1,2-DIHYDROXY DERIVATIVES - DETERMINATION OF THE REGIOCHEMISTRY AND STEREOCHEMISTRY OF THE OXIDATION REACTIONS

Authors
BESTETTI G BIANCHI D BOSETTI A DIGENNARO P GALLI E LEONI B PELIZZONI F SELLO G
Citation
G. Bestetti et al., BIOCONVERSION OF SUBSTITUTED NAPHTHALENES TO THE CORRESPONDING 1,2-DIHYDRO-1,2-DIHYDROXY DERIVATIVES - DETERMINATION OF THE REGIOCHEMISTRY AND STEREOCHEMISTRY OF THE OXIDATION REACTIONS, Applied microbiology and biotechnology, 44(3-4), 1995, pp. 306-313
Citations number
16
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Applied microbiology and biotechnology → ACNP
ISSN journal
01757598
Volume
44
Issue
3-4
Year of publication
1995
Pages
306 - 313
Database
ISI
SICI code
0175-7598(1995)44:3-4<306:BOSNTT>2.0.ZU;2-9
Abstract
A mutant (TTC1) derived from Pseudomonas fluorescens N3 has been obtai ned for use in the bioconversion of several naphthalene derivatives to the corresponding optically active cis-dihydrodiols on a milligrams-t o-grams scale. All main compounds have been characterized, their relat ive and absolute configuration assigned, and their enantiomeric purity determined. The regio- and stereoselectivity of the transformation ha s been established. The procedure therefore represents a valid method for the convenient preparation of a pool of valuable chiral syntons an d auxiliaries.