INFLUENCE OF MOLSIDOMINE ON THE FIBRINOLY TIC CAPACITY AND OTHER HEMOSTATIC PARAMETERS IN PATIENTS WITH CORONARY HEART-DISEASE

Authors
SCHMUTZLER H STORK T ROCKER L
Citation
H. Schmutzler et al., INFLUENCE OF MOLSIDOMINE ON THE FIBRINOLY TIC CAPACITY AND OTHER HEMOSTATIC PARAMETERS IN PATIENTS WITH CORONARY HEART-DISEASE, Herz, Kreislauf, 27(12), 1995, pp. 423-427
Citations number
36
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Herz, Kreislauf → ACNP
ISSN journal
00467324
Volume
27
Issue
12
Year of publication
1995
Pages
423 - 427
Database
ISI
SICI code
0046-7324(1995)27:12<423:IOMOTF>2.0.ZU;2-7
Abstract
31 patients with chronic coronary heart disease were studied in a rand omized, placebo-controlled trial. The effect of a single dose of 8 mg molsidomine (versus placebo) on different parameters of the coagulatio n and particularly on the fibrinolytic system was studied. Whereas t-P A, PAI-1, PT and PTT showed no differences, the fibrinogen level was s ignificantly decreased due to molsidomine. Therefore, beside the antii schemic in dication a further therapeutic aspect is given for the prim ary and secondary prevention of coronary heart disease.