CLINICAL GENETIC-ASPECTS OF CUTANEOUS MAL IGNANT-MELANOMA .2. INTERRELATION AND PATHOGENETIC COMMONALITY WITH DYSPLASTIC NEVUS SYNDROME

Citation
Gy. Kharkevich et al., CLINICAL GENETIC-ASPECTS OF CUTANEOUS MAL IGNANT-MELANOMA .2. INTERRELATION AND PATHOGENETIC COMMONALITY WITH DYSPLASTIC NEVUS SYNDROME, Genetika, 31(11), 1995, pp. 1562-1565
Citations number
19
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
00166758
Volume
31
Issue
11
Year of publication
1995
Pages
1562 - 1565
Database
ISI
SICI code
0016-6758(1995)31:11<1562:CGOCMI>2.0.ZU;2-2
Abstract
Evidence for the role of dysplastic nevi (DN) in the development of cu taneous malignant melanoma (CMM) is presented. Primary multiple foci d f CMM were found considerably more frequently in individuals with DN. The frequency of primary multiple CMM was found to be 3.1% in males wi th DN and 0.9% in males without DN; in females, 6.8 and 0.6%, respecti vely. Genetic correlation analysis was performed to determine the gene tic interrelation between DN and CMM. In general, the genetic correlat ion coefficient was 0.9; i.e., predisposition to DN and CMM is determi ned by common genes for 90%. The frequency and distribution of constit utive fragile sites in chromosomes of peripheral lymphocytes was studi ed by the method of principal components for discrete variables. The s ite 1p22 is responsible for variability of the traits CMM and DN for 9 8.5%. On the one hand, this suggests that one of the supposed genes fo r CMM can be located at 1p22; on the other hand, CMM and DN are likely to have a common genetic determination or to be very tightly linked. Estimates of risk for the development of CMM in patients' relatives ar e given with reference to the variants of CMM manifestation and presen ce of DN.