Gy. Kharkevich et al., CLINICAL GENETIC-ASPECTS OF CUTANEOUS MAL IGNANT-MELANOMA .2. INTERRELATION AND PATHOGENETIC COMMONALITY WITH DYSPLASTIC NEVUS SYNDROME, Genetika, 31(11), 1995, pp. 1562-1565
Evidence for the role of dysplastic nevi (DN) in the development of cu
taneous malignant melanoma (CMM) is presented. Primary multiple foci d
f CMM were found considerably more frequently in individuals with DN.
The frequency of primary multiple CMM was found to be 3.1% in males wi
th DN and 0.9% in males without DN; in females, 6.8 and 0.6%, respecti
vely. Genetic correlation analysis was performed to determine the gene
tic interrelation between DN and CMM. In general, the genetic correlat
ion coefficient was 0.9; i.e., predisposition to DN and CMM is determi
ned by common genes for 90%. The frequency and distribution of constit
utive fragile sites in chromosomes of peripheral lymphocytes was studi
ed by the method of principal components for discrete variables. The s
ite 1p22 is responsible for variability of the traits CMM and DN for 9
8.5%. On the one hand, this suggests that one of the supposed genes fo
r CMM can be located at 1p22; on the other hand, CMM and DN are likely
to have a common genetic determination or to be very tightly linked.
Estimates of risk for the development of CMM in patients' relatives ar
e given with reference to the variants of CMM manifestation and presen
ce of DN.