INFLUENCE OF ACUTE-HYPOXIA ON THE CYTOGEN ETIC EFFECT OF CYCLOPHOSPHAMIDE IN CELLS OF BONE-MARROW OF RATS WITH DIFFERENT RESISTANCES TO OXYGEN DEFICIENCY

The frequency of chromosomal aberrations in rat bone marrow cells inje cted with intraperitoneal cyclophosphamide (CF) during the 24 h after acute hypoxia was studied. We used two groups of rats: a group with lo w resistance (LR) to acute hypoxia that was unable to endure more than 5 min in a vacuum chamber at the altitude of 11 000 m, and a group of highly resistant (HR) rats able to endure 25 min or longer under the above conditions in vacuum chamber. Acute hypoxia was shown to enhance the cytogenetic activity of cyclophosphamide, and the number of chrom osomal aberrations was higher in HR rats than in LR animals.