SYNTHESIS OF SOME NEW PIPERAZINE-N,N'-BIS-SUBSTITUTED DERIVATIVES AS POTENTIAL BIOLOGICALLY-ACTIVE AGENTS

In a search for new bactericidal and fungicidal agents some new pipera zine-N,N'-bis-substituted derivatives have been prepared and character ized by their elemental analysis, IR, H-1 NMR, and mass spectral data. The antibacterial and antifungal activities of all prepared compounds have been determined using Gentamycin as standard antibiotic. Some co mpounds showed a high activity equivalent to that of the standard towa rds Escherichia coli, Serratia marcescens, Bacillus cereus, Staphyloco ccus aureus, and Candida albicans.