THE EFFECT OF BIO-ANTIMUTAGENS ON CHLORAMBUCIL AND METHOTREXATE USINGTHE WING SPOT-TEST IN DROSOPHILA-MELANOGASTER

When certain mutagenic anti-cancer medicines are used for cancer thera py, secondary production of cancer by the medicines themselves is fear ed. Certain bio-antimutagenic substances may decrease secondary cancer induction without interfering with the effectiveness of the anti-canc er therapies. The bio-antimutagenic effects of cobaltous chloride, gal lic acid, taurine and isethionate on the anti-cancer medicines chloram bucil and methotrexate were investigated using the Drosophila melanoga ster wing spot test. Cobaltous chloride reduced the mutagenicity of me thotrexate, but not chlorambucil. Gallic acid reduced the mutagenicity of both medicines. Taurine and isethionate also reduced the mutagenic ity of methotrexate.