MEMBRANE VANADIUM INTERACTION - A TOXICOKINETIC EVALUATION

Vanadium is an important trace metal widely distributed in environment . Interaction of vanadate with skeletal muscle sarcolemma and basement membrane has been focussed. Scatchard analysis indicated the presence of more than one binding site for vanadate. Vanadate inhibits sarcole mmal and intestinal brush border membrane enzymes in a non-competitive manner. Membrane-vanadium interaction may lead to several structural and functional changes. The binding of vanadium to basement membrane m ay have some protective role.