FACTORS ASSOCIATED WITH CYTOMEGALOVIRUS-INFECTION AMONG HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1-SERONEGATIVE AND TYPE-1-SEROPOSITIVE WOMEN FROMAN URBAN MINORITY COMMUNITY

Cytomegalovirus (CMV) seroprevalence and genital tract shedding in hum an immunodeficiency virus (HIV)-seronegative and HIV-seropositive wome n from an urban minority community were investigated. CMV seropositivi ty was high in both groups: 181 (95.2%) of 190 HIV-negative and 158 (9 0.3%) of 175 HIV-positive subjects. Cervicovaginal shedding was detect ed in 8 (4.4%) CMV-positive HIV-negative subjects and 31 (19.6%) HIV-p ositive subjects (odds ratio [OR], 5.28; P < .001), Multiple logistic regression analysis revealed that CMV shedding was independently assoc iated with younger age (OR = 0.90; P < .001) and concurrent Chlamydia trachomatis or Neisseria gonorrhoeae infection (OR = 3.60; P = .08). H owever, shedding was observed over a broad age range in HIV-positive s ubjects, with 54.8% of shedders being greater than or equal to 30 year s old. Among HIV-positive subjects, CMV shedding was also associated w ith decreased CD4 cell counts (P = .04) and, compared with HIV-negativ e subjects, was significantly higher (P < .001) among subjects with CD 4 cell counts <500 X 10(6)/L (26.5% in subjects with counts less than or equal to 200 and 22.1% in subjects with counts of 201-499 X 10(6)/L ).