CRYPTOSPORIDIUM-PARVUM - INTENSITY OF INFECTION AND OOCYST EXCRETION PATTERNS IN HEALTHY-VOLUNTEERS

Citation
Cl. Chappell et al., CRYPTOSPORIDIUM-PARVUM - INTENSITY OF INFECTION AND OOCYST EXCRETION PATTERNS IN HEALTHY-VOLUNTEERS, The Journal of infectious diseases, 173(1), 1996, pp. 232-236
Citations number
20
Categorie Soggetti
Infectious Diseases
ISSN journal
00221899
Volume
173
Issue
1
Year of publication
1996
Pages
232 - 236
Database
ISI
SICI code
0022-1899(1996)173:1<232:C-IOIA>2.0.ZU;2-Q
Abstract
Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infec ted with the human immunodeficiency virus, In addition, experimental i nfection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection response of C. parvum (Iowa strain), In that report, low inocula were sufficient to cause infection in 18 and illness in 7 persons, To further define the duration and intensity of infection in this population, oocyst shedding patterns were invest igated in the 18 subjects infected with C. parvum. Oocyst quantitation revealed that volunteers with diarrheal illness (n = 7) excreted more oocysts over the course of the infection than did volunteers without diarrhea (n = 11; P < .05). Symptomatic subjects were more likely to s hed oocysts on consecutive days, Further, a statistical nonsignificant inverse trend (r(2) = .330, P = .136) was seen between challenge dose and total excreted oocysts, This paradox may relate to receptor satur ation or a toxic effect on cells, parasites, or both afforded by a hig h inoculum.