IDENTIFICATION OF POLYMORPHISM AT THE GLUTATHIONE-S-TRANSFERASE, GSTM3 LOCUS - EVIDENCE FOR LINKAGE WITH GSTM1-ASTERISK-A

Allelism in the glutathione S-transferase, GSTM3 gene has been identif ied using PCR with specific primers to exon 6/exon 7. Sequencing showe d the mutant GSTM3B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequen ce, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3B w as significantly associated with GSTM1A.