ENANTIOSPECIFIC INHIBITION OF EMESIS INDUCED BY NICOTINE IN THE HOUSEMUSK SHREW (SUNCUS-MURINUS) BY THE NEUROKININ(1) (NK1) RECEPTOR ANTAGONIST CP-99,994

Authors
TATTERSALL FD RYCROFT W MARMONT N CASCIERI M HILL RG HARGREAVES RJ
Citation
Fd. Tattersall et al., ENANTIOSPECIFIC INHIBITION OF EMESIS INDUCED BY NICOTINE IN THE HOUSEMUSK SHREW (SUNCUS-MURINUS) BY THE NEUROKININ(1) (NK1) RECEPTOR ANTAGONIST CP-99,994, Neuropharmacology, 34(12), 1995, pp. 1697-1699
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
34
Issue
12
Year of publication
1995
Pages
1697 - 1699
Database
ISI
SICI code
0028-3908(1995)34:12<1697:EIOEIB>2.0.ZU;2-7
Abstract
Effects of the NK1 receptor antagonist CP-99,994 on nicotine-induced e mesis were examined in Suncus murinus. CP-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). CP-100,263 (3 and 10 mg/kg i.p.), the enantiomer of CP-99,994 with 1000 fold lower affinit y for the NK1 receptor was without effect and RP67580 reduced emesis o nly at a dose of 30 mg/kg i.p. Responses to NK1 antagonists were ranke d according to their affinities for the Suncus murinus NK1 receptor.