MICROCEPHALY AND EARLY-ONSET NEPHROTIC SYNDROME CONFUSION IN GALLOWAY-MOWAT SYNDROME

We report a 2-year-old girl with nephrotic syndrome, microcephaly, sei zures and psychomotor retardation, Histological studies of a renal bio psy revealed focal glomerular sclerosis with mesangiolysis and capilla ry microaneurysms. Dysmorphic features were remarkable: abnormal-shape d skull, coarse hair, narrow forehead, large low-set ears, almond-shap ed eyes, low nasal bridge, pinched nose, thin lips and micrognathia. C ases with this rare combination of microcephaly and early onset of nep hrotic syndrome with various neurological abnormalities have been repo rted, However, clinical manifestations and histological findings showe d a wide variation, and there is a lot of confusion in this syndrome. We therefore reviewed the previous reports and propose a new classific ation of this syndrome.