The primary disorders of 50 children with increased renal medullary ec
hogenicity on renal ultrasound were studied; 28 girls and 22 boys aged
from 1 month to 16 years were classified into four groups based on un
derlying disease and ultrasound findings. Group 1 was composed of 17 p
atients with distal renal tubular acidosis (34%); intense echoes throu
ghout the pyramid were predominant, Group 2 consisted of 14 patients w
ith vitamin D toxicity (28%) and an intense echogenic rim around the p
yramids. Group 3 included 10 patients with different types of tubulopa
thies. A slight hyperechogenic rim around the sides and tip of the med
ullary pyramids was detected. Group 4 was made up of 9 patients with r
are underlying conditions. Abdominal X-rays detected medullary calcino
sis in only 12 (24%) of the total 50 patients. Ultrasonography appears
to be an important tool in the early diagnosis of increased renal med
ullary echogenicity and medullary nephrocalcinosis.