M. Davanzo et al., CONCEALED ADMINISTRATION OF FRUSEMIDE SIMULATING BARTTER-SYNDROME IN A 4.5-YEAR-OLD BOY, Pediatric nephrology, 9(6), 1995, pp. 749-750
A 4.5-year-old boy was admitted to three different hospitals because o
f a tendency towards dehydration and polyuria, along with normal blood
pressure, hypochloraemia, hypokalaemia, metabolic alkalosis and an im
paired urinary concentrating ability, A renal biopsy failed to reveal
juxtaglomerular hyperplasia. The clinical and laboratory findings fail
ed to improve despite supplementation with potassium chloride and trea
tment with indomethacin. The urine was found to contain frusemide, The
parents denied any drug administration to the boy, The child is now d
oing well more than I year after separation from his mother, Since ing
estion of diuretic cannot be differentiated from true Bartter syndrome
by blood and urinary electrolyte measurements alone, a diuretic scree
n is warranted in children with findings consistent with Bartter syndr
ome.