We report the development of chylous ascites in a neonate as an uncomm
on complication during continuous peritoneal dialysis. Cloudy dialysis
fluid containing many white blood cells might confuse the diagnosis o
f chylous ascites with infective peritonitis and result in inappropria
te use of antibiotics. Resolution may be critical, since chyle removal
during dialysis may result in profound immunosuppression and malnutri
tion due to lymphocyte and fat losses. After 4 weeks on a modified die
t, the chyle leak resolved. The patient returned to breast milk and co
ntinues nighttime continuous-cycle peritoneal dialysis without further
chyle leak.