STACHYBOCINS, NOVEL ENDOTHELIN RECEPTOR ANTAGONISTS, PRODUCED BY STACHYBOTRYS SP M6222 .2. STRUCTURE DETERMINATION OF STACHYBOCIN-A, STACHYBOCIN-B AND STACHYBOCIN-C

Authors
OGAWA K NAKAMURA M HAYASHI M YAGINUMA S YAMAMOTO S FURIHATA K SHINYA K SETO H
Citation
K. Ogawa et al., STACHYBOCINS, NOVEL ENDOTHELIN RECEPTOR ANTAGONISTS, PRODUCED BY STACHYBOTRYS SP M6222 .2. STRUCTURE DETERMINATION OF STACHYBOCIN-A, STACHYBOCIN-B AND STACHYBOCIN-C, Journal of antibiotics, 48(12), 1995, pp. 1396-1400
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
12
Year of publication
1995
Pages
1396 - 1400
Database
ISI
SICI code
0021-8820(1995)48:12<1396:SNERAP>2.0.ZU;2-W
Abstract
The structures of stachybocins A, B and C, new endothelin receptor ant agonists, were determined by NMR spectral analysis using pulse-field-g radient techniques. Stachybocin A consists of two spirobenzofuran unit s each fused to a substituted decalin, which were connected by a lysin e residue. Stachybocins B and C are derivatives of stachybocin A with an additional hydroxy group at the same position in the different deca lin unit.