PHENOPYRROZIN, A NEW RADICAL SCAVENGER PRODUCED BY PENICILLIUM SP FO-2047

Authors
SHIOMI K YANG H XU Q ARAI N NAMIKI M HAYASHI M INOKOSHI J TAKESHIMA H MASUMA R KOMIYAMA K OMURA S
Citation
K. Shiomi et al., PHENOPYRROZIN, A NEW RADICAL SCAVENGER PRODUCED BY PENICILLIUM SP FO-2047, Journal of antibiotics, 48(12), 1995, pp. 1413-1418
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
12
Year of publication
1995
Pages
1413 - 1418
Database
ISI
SICI code
0021-8820(1995)48:12<1413:PANRSP>2.0.ZU;2-#
Abstract
A new radical scavenger, named phenopyrrozin, was isolated from the cu lture broth of Penicillium sp. FO-2047. Phenopyrrozin was purified fro m whole broth by solvent extraction, silica gel chromatography, and HP LC. The structure of phenopyrrozin was elucidated as 5,6,7,7a-tetrahyd ro-2-hydroxy-1-phenyl- 3H-pyrrolizin-3-one. The IC50 of phenopyrrozin against lipid peroxidation induced by Cr2K2O7 was 73 mu g/ml. Phenopyr rozin also reduced chromosomal aberrations induced by paraquat.