RAKICIDINS, NEW CYTOTOXIC LIPOPEPTIDES FROM MICROMONOSPORA SP FERMENTATION, ISOLATION AND CHARACTERIZATION

Authors
MCBRIEN KD BERRY RL LOWE SE NEDDERMANN KM BURSUKER I HUANG S KLOHR SE LEET JE
Citation
Kd. Mcbrien et al., RAKICIDINS, NEW CYTOTOXIC LIPOPEPTIDES FROM MICROMONOSPORA SP FERMENTATION, ISOLATION AND CHARACTERIZATION, Journal of antibiotics, 48(12), 1995, pp. 1446-1452
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
12
Year of publication
1995
Pages
1446 - 1452
Database
ISI
SICI code
0021-8820(1995)48:12<1446:RNCLFM>2.0.ZU;2-Y
Abstract
The new cytotoxic agents rakicidins A and B were isolated from culture d broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2,4-dienoic acid. 3-hydroxy-2,4,16-trimethyl-heptadecano ic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by on e methylene group in the lipid side chain. These compounds exhibited c ytotoxicity against the M109 cell line.