STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF SEMISYNTHETIC SPICAMYCINDERIVATIVES

Authors
SAKAI T KAWAI H KAMISHOHARA M ODAGAWA A SUZUKI A UCHIDA T KAWASAKI T TSURUO T OTAKE N
Citation
T. Sakai et al., STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF SEMISYNTHETIC SPICAMYCINDERIVATIVES, Journal of antibiotics, 48(12), 1995, pp. 1467-1480
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
12
Year of publication
1995
Pages
1467 - 1480
Database
ISI
SICI code
0021-8820(1995)48:12<1467:SAROSS>2.0.ZU;2-A
Abstract
New derivatives of spicamycin modified at the fatty acid moieties of t he molecule were synthesized and their structure-activity relationship s were examined. The antitumor activity was greatly influenced by modi fication of the fatty acid moieties to tetradecadienoyl or dodecadieno yl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.