L. Poluektova et al., IMMUNOSTIMULATING PROPERTIES OF THE COMPLEXES OF INOSINE DERIVATIVES, International journal of immunopharmacology, 17(11), 1995, pp. 941-947
The effects of the complexes of inosine (Ino) analogues of isoprinosin
e on the immune response to sheep red blood cells (SRBC), in plaque-fo
rming cells assay (PFC), in mice spleen, and on the Fc-dependent SRBC
phagocytosis in mice peritoneal macrophages were investigated. Molar r
atios of 1:3 of the complexes of inosine with N,N-dimethylaminopropano
l-2-p-acetaminobenzoate (isoprinosine), and 8-thioinosine with N,N-dim
ethylaminopropanol-2-p-acetaminobenzoate (OSI-177), inosine with L-arg
inine butyrate (OSI-2655), and 8-thioinosine with L-arginine butyrate
(OSI-3648) were administered. The administered doses were 0.5, 5 and 5
0 mg/kg body weight. The compound 081-2655 exceeded isoprinosine in PF
C stimulation and phagocytosis activation. The compound OSI-3648 excee
ded isoprinosine only in PFC stimulation in the case ofimmunization wi
th a suboptimal SRBC dose. OSI-3648 stimulated the immune response in
PFC better than isoprinosine, OSI-177, or OSI-2655, and maintained the
ability to stimulate capture, but lost the ability to stimulate destr
uction processes of captured SRBC. L-Arginine butyrate in the doses eq
uivalent to its content in the complexes did not affect the number of
PFC. L-Arginine butyrate was able to stimulate the processes of destru
ction but its stimulation degree was inferior to the compound OSI-2655
.