IMMUNOSTIMULATING PROPERTIES OF THE COMPLEXES OF INOSINE DERIVATIVES

The effects of the complexes of inosine (Ino) analogues of isoprinosin e on the immune response to sheep red blood cells (SRBC), in plaque-fo rming cells assay (PFC), in mice spleen, and on the Fc-dependent SRBC phagocytosis in mice peritoneal macrophages were investigated. Molar r atios of 1:3 of the complexes of inosine with N,N-dimethylaminopropano l-2-p-acetaminobenzoate (isoprinosine), and 8-thioinosine with N,N-dim ethylaminopropanol-2-p-acetaminobenzoate (OSI-177), inosine with L-arg inine butyrate (OSI-2655), and 8-thioinosine with L-arginine butyrate (OSI-3648) were administered. The administered doses were 0.5, 5 and 5 0 mg/kg body weight. The compound 081-2655 exceeded isoprinosine in PF C stimulation and phagocytosis activation. The compound OSI-3648 excee ded isoprinosine only in PFC stimulation in the case ofimmunization wi th a suboptimal SRBC dose. OSI-3648 stimulated the immune response in PFC better than isoprinosine, OSI-177, or OSI-2655, and maintained the ability to stimulate capture, but lost the ability to stimulate destr uction processes of captured SRBC. L-Arginine butyrate in the doses eq uivalent to its content in the complexes did not affect the number of PFC. L-Arginine butyrate was able to stimulate the processes of destru ction but its stimulation degree was inferior to the compound OSI-2655 .