EFFECTS OF NOVEL 3,4-BISPHENYLHEX(3)ENES ON CELL-PROLIFERATION IN MALIGNANT AND NORMAL-CELLS

Authors
PECHAN R SCHULER M SLANY M BECK R PFEIFFER E METZLER M
Citation
R. Pechan et al., EFFECTS OF NOVEL 3,4-BISPHENYLHEX(3)ENES ON CELL-PROLIFERATION IN MALIGNANT AND NORMAL-CELLS, Cancer letters, 98(2), 1996, pp. 163-168
Citations number
15
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
98
Issue
2
Year of publication
1996
Pages
163 - 168
Database
ISI
SICI code
0304-3835(1996)98:2<163:EON3OC>2.0.ZU;2-H
Abstract
The growth-inhibitory effect of several newly synthesized alkyl deriva tives of 3,4-bisphenylhex(3)ene was studied in four tumor cell lines a nd three healthy primary cell systems. A marked inhibition of cell pro liferation was noted in the neoplastic cells but not in the primary sy stems. No effect on the cytoplasmic or mitotic microtubule system but an increase in the gross level of 5-methylcytosine in nuclear DNA was observed. It is speculated that the selective growth inhibition of tum or cells is due to DNA-hypermethylation.