EFFECT OF INTRAVENOUS LIDOCAINE ON INTRAABDOMINAL PRESSURE RESPONSE TO AIRWAY STIMULATION

We evaluated the effect of intravenous (IV) lidocaine (1 or 2 mg/kg) o n increases in intraabdominal pressure (IAP) due to carinal stimulatio n in anesthetized patients. IAP was measured continuously using a tran surethral bladder catheter. Before administration of lidocaine, carina l stimulation by suction catheter increased IAP compared with baseline values (P < 0.05). After IV administration of 1 mg/kg of lidocaine, c arinal stimulation produced no change in IAP for 5 min, but IAP increa sed more than baseline at 7 min (P < 0.05); 2 mg/kg of lidocaine suppr essed increase in IAP due to carinal stimulation until 7 min. Changes in IAP at 7 min were 42.2 +/- 12.2 mm Hg in the 1 mg/kg group and 10.8 +/- 2.6 mm Hg in the 2 mg/kg (P < 0.05). We conclude that increase in IAP caused by carinal stimulation is attenuated by IV Lidocaine, and this effect continues for 5 min from 1 mg/kg of Lidocaine and at least for 7 min from 2 mg/kg after administration.